The Journal of organic chemistry

Asymmetric synthesis of δ-substituted α, β-unsaturated δ-lactams by ring closing metathesis of enantiomerically pure N-acryloyl-homoallylic amines

C Fiorelli, D Savoia

Index: Fiorelli, Claudio; Savoia, Diego Journal of Organic Chemistry, 2007 , vol. 72, # 16 p. 6022 - 6028

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Citation Number: 31

Abstract

Optically pure secondary homoallylic amines, obtained by highly diastereoselective addition of allylmetal reagents to imines derived from chiral amines, were N-dealkylated, and the primary amines were converted to N-acryloyl amides. Then, ring closing metathesis gave δ- substituted δ-lactams in good overall yields.