The Journal of organic chemistry

Asymmetric synthesis of δ-substituted α, β-unsaturated δ-lactams by ring closing metathesis of enantiomerically pure N-acryloyl-homoallylic amines

C Fiorelli, D Savoia

文献索引：Fiorelli, Claudio; Savoia, Diego Journal of Organic Chemistry, 2007 , vol. 72, # 16 p. 6022 - 6028

全文：HTML全文

被引用次数: 31

摘要

Optically pure secondary homoallylic amines, obtained by highly diastereoselective addition of allylmetal reagents to imines derived from chiral amines, were N-dealkylated, and the primary amines were converted to N-acryloyl amides. Then, ring closing metathesis gave δ- substituted δ-lactams in good overall yields.