Free-Wilson and structural approaches to co-optimizing human and rodent isoform potency for 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors

FW Goldberg, AG Leach, JS Scott…

Index: Journal of Medicinal Chemistry, , vol. 55, # 23 p. 10652 - 10661

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Citation Number: 18

Abstract

... Journal of Medicinal Chemistry. ... 11β-Hydroxysteroid dehydrogenase 1 (11β-HSD1) has been a target of intensive research efforts across the pharmaceutical industry, due to its potential for the treatment of type II diabetes and other elements of the metabolic syndrome. ...