Free-Wilson and structural approaches to co-optimizing human and rodent isoform potency for 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors
FW Goldberg, AG Leach, JS Scott…
文献索引：Journal of Medicinal Chemistry, , vol. 55, # 23 p. 10652 - 10661
... Journal of Medicinal Chemistry. ... 11β-Hydroxysteroid dehydrogenase 1 (11β-HSD1) has been a target of intensive research efforts across the pharmaceutical industry, due to its potential for the treatment of type II diabetes and other elements of the metabolic syndrome. ...
