Synthesis and biological properties of cholecystokinin heptapeptide analogues containing D-and L-forms of tert-leucine or neopentylglycine in position 5

…, J Pospíšek, J Slaninová, L Maletínská

Index: Hlavacek, Jan; Pirkova, Jana; Pospisek, Jan; Slaninova, Jirina; Maletinska, Lenka Collection of Czechoslovak Chemical Communications, 1991 , vol. 56, # 10 p. 2209 - 2217

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Abstract

Abstract Using solution or solid-phase synthesis we prepared the cholecystokinin fragment Boc-CCK-7 (Boc-Tyr-(SO 3-. Na+)-Met-Gly-Trp-Met-Asp-PheNH 2) and its four analogues in which the methionine moiety (Met) in the carboxy-terminal part is replaced by tert-leucine (Tle) or neopentylglycine (Neo) residue or D-enantiomers of these non-coded amino acids. These structural modifications led to reduction of the studied biological activities (gall ...