Synthesis of the carboxy-terminal octapeptide of cholecystokinin (CKK-8) based on incorporation of O 4-sulfotyrosine by enzymatically catalyzed formation of peptide …

V Čeřovský, J Hlaváček, J Slaninová…

Index: Cerovsky, Vaclav; Hlavacek, Jan; Slaninova, Jirina; Jost, Karel Collection of Czechoslovak Chemical Communications, 1988 , vol. 53, # 5 p. 1086 - 1093

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Citation Number: 4

Abstract

Abstract Papain-catalyzed condensation of sodium salt of tert-butyloxycarbonyl-β-tert- butyloxyaspartyl-O 4-sulfotyrosine (fragment 1-2) with methionyl-glycyl-tryptophyl-methionyl- aspartyl-phenylalanine amide (fragment 3-8) has been elaborated. Deprotection of the thus- obtained octapeptide afforded CCK-8 which exhibited full biological activities. Benzyloxycarbonylaspartyl-phenylalanine amide (fragment 7-8) was prepared using ...