Synthesis of 2-substituted 5-(1-oxido-4-pyridyl)-and 5-(1-oxido-2-pyridyl)-1, 3, 4-thiadiazole derivatives by substitution of 2-methylsulfonyl group with various …

K TOYOOKA, Y KAWASHIMA, S KUBOTA

Index: Toyooka, Kouhei; Kawashima, Yasushi; Kubota, Seiju Chemical & Pharmaceutical Bulletin, 1987 , vol. 35, # 3 p. 1030 - 1035

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Citation Number: 5

Abstract

The synthesis of 2-substituted 5-(1-oxido-4-pyridy1)-(4a-10a) and 5-(1-oxido-2-pyridyl)-1, 3, 4-thiadiazole derivatives (4b-10) by substitution reaction of 5-(1-oxido-4-pyridyl)-(3a) and 5- (1-oxido-2-pyridyl)-2-methylsulfonyl-1, 3, 4-thiadiazole (3b) is described. 5-(1-Oxido-4- pyridyl)-(9a) and 5-(1-oxido-2-pyridyl)-1, 3, 4-thiadiazole (9b) could be reduced with sodium dithionite to 2-(4-pyridyl)-(11c) and 2-(2-pyridyl)-1, 3, 4-thiadiazole (11d)