Synthesis of 2-substituted 5-(1-oxido-4-pyridyl)-and 5-(1-oxido-2-pyridyl)-1, 3, 4-thiadiazole derivatives by substitution of 2-methylsulfonyl group with various …
K TOYOOKA, Y KAWASHIMA, S KUBOTA
文献索引：Toyooka, Kouhei; Kawashima, Yasushi; Kubota, Seiju Chemical & Pharmaceutical Bulletin, 1987 , vol. 35, # 3 p. 1030 - 1035
The synthesis of 2-substituted 5-(1-oxido-4-pyridy1)-(4a-10a) and 5-(1-oxido-2-pyridyl)-1, 3, 4-thiadiazole derivatives (4b-10) by substitution reaction of 5-(1-oxido-4-pyridyl)-(3a) and 5- (1-oxido-2-pyridyl)-2-methylsulfonyl-1, 3, 4-thiadiazole (3b) is described. 5-(1-Oxido-4- pyridyl)-(9a) and 5-(1-oxido-2-pyridyl)-1, 3, 4-thiadiazole (9b) could be reduced with sodium dithionite to 2-(4-pyridyl)-(11c) and 2-(2-pyridyl)-1, 3, 4-thiadiazole (11d)
