Journal of Sulfur Chemistry

Sodium carbonate-mediated facile synthesis of 4-substituted-2-(3, 5-dimethylpyrazol-1-yl) thiazoles under solvent-free conditions

R Aggarwal, S Kumar, SP Singh

Index: Aggarwal, Ranjana; Kumar, Sunil; Singh, Shiv P. Journal of Sulfur Chemistry, 2012 , vol. 33, # 5 p. 521 - 525,5

Full Text: HTML

Citation Number: 3

Abstract

An efficient and facile synthesis of 4-substituted-2-(3, 5-dimethylpyrazol-1-yl) thiazoles 3 was achieved by grinding an equimolar mixture of α-haloketones 2 with 3, 5-dimethylpyrazol-1- thiocarboxamide 1 in the presence of sodium carbonate under the solvent-free conditions. The present methodology offers an eco-friendly, mild, efficient (92–96%), and rapid method (5 min) for the synthesis of 3 besides preventing the formation of α-thiocyanatoketones as ...