An efficient and facile synthesis of 4-substituted-2-(3, 5-dimethylpyrazol-1-yl) thiazoles 3 was achieved by grinding an equimolar mixture of α-haloketones 2 with 3, 5-dimethylpyrazol-1- thiocarboxamide 1 in the presence of sodium carbonate under the solvent-free conditions. The present methodology offers an eco-friendly, mild, efficient (92–96%), and rapid method (5 min) for the synthesis of 3 besides preventing the formation of α-thiocyanatoketones as ...
