7-Azabicyclo [2.2. 1] heptane as a scaffold for the development of selective sigma-2 (σ 2) receptor ligands

SD Banister, LM Rendina, M Kassiou

Index: Banister, Samuel D.; Rendina, Louis M.; Kassiou, Michael Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 12 p. 4059 - 4063

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Citation Number: 7

Abstract

A series of N-substituted 7-azabicyclo [2.2. 1] heptanes (12–17 and 22–25) and similarly substituted pyrrolidines (32–36 and 41–44) were synthesized as sterically-reduced, achiral analogs of adamantane-and trishomocubane-derived σ ligands. In vitro competition binding assays against σ receptors revealed that arylalkyl N-substituents conferred selectivity for the σ2 subtype, while alicyclic or polycarbocyclic substituents imparted high affinity for both ...