Advanced synthesis & catalysis

A General and Practical Palladium??Catalyzed Direct α??Arylation of Amides with Aryl Halides

B Zheng, T Jia, PJ Walsh

Index: Zheng, Bing; Jia, Tiezheng; Walsh, Patrick J. Advanced Synthesis and Catalysis, 2014 , vol. 356, # 1 p. 165 - 178

Full Text: HTML

Citation Number: 26

Abstract

Abstract: An efficient system for the direct catalytic intermolecular α-arylation of acetamide derivatives with aryl bromides and chlorides is presented. The palladium catalyst is supported by Kwong s indolebased phosphine ligand and provides monoarylated amides in up to 95% yield. Excellent chemoselectivities (> 10: 1) in the mono-and diarylation with aryl bromides were achieved by careful selection of bases, solvents, and stoichiometry. Under ...

 Related Synthetic Route
N-Acetylmorpholine Structure

1696-20-4

N-Acetylmorpholine

Bromobenzene Structure

108-86-1

Bromobenzene

~90%

Ethanone,1-(4-morpholinyl)-2-phenyl- Structure

17123-83-0

Ethanone,1-(4-m...

N,N-Diethylacetamide Structure

685-91-6

N,N-Diethylacetamide

4-Bromoanisole Structure

104-92-7

4-Bromoanisole

~92%

N,N-Diethyl-2-(4-methoxyphenyl)acetamide Structure

115348-15-7

N,N-Diethyl-2-(...

N,N-Diethylacetamide Structure

685-91-6

N,N-Diethylacetamide

1-Chloro-4-methoxybenzene Structure

623-12-1

1-Chloro-4-meth...

~70%

N/A Structure

1449216-36-7

N/A

N,N-Diethyl-2-(4-methoxyphenyl)acetamide Structure

115348-15-7

N,N-Diethyl-2-(...

N-Acetylpyrrolidine Structure

4030-18-6

N-Acetylpyrrolidine

Bromobenzene Structure

108-86-1

Bromobenzene

~85%

6-Methoxy-2-(methylsulfanyl)-4-pyrimidinamine Structure

3389-53-5

6-Methoxy-2-(me...

N-(2-bromophenyl)-N-methylacetamide Structure

153704-11-1

N-(2-bromopheny...

~78%

2,3-Dihydro-1-methylindol-2-one Structure

61-70-1

2,3-Dihydro-1-m...

N,N-Diethylacetamide Structure

685-91-6

N,N-Diethylacetamide

Chlorobenzene Structure

108-90-7

Chlorobenzene

~79%

Benzeneacetamide,N,N-diethyl-a-phenyl- Structure

3004-58-8

Benzeneacetamid...

N,N-Diethylacetamide Structure

685-91-6

N,N-Diethylacetamide

Bromobenzene Structure

108-86-1

Bromobenzene

~96%

Benzeneacetamide,N,N-diethyl-a-phenyl- Structure

3004-58-8

Benzeneacetamid...

Bromobenzene Structure

108-86-1

Bromobenzene

N,N-diethyl-2-phenylacetamide Structure

2431-96-1

N,N-diethyl-2-p...

~91%

Benzeneacetamide,N,N-diethyl-a-phenyl- Structure

3004-58-8

Benzeneacetamid...

N,N-diethyl-2-phenylacetamide Structure

2431-96-1

N,N-diethyl-2-p...

Chlorobenzene Structure

108-90-7

Chlorobenzene

~92%

Benzeneacetamide,N,N-diethyl-a-phenyl- Structure

3004-58-8

Benzeneacetamid...

N,N-Diethylacetamide Structure

685-91-6

N,N-Diethylacetamide

Bromobenzene Structure

108-86-1

Bromobenzene

~80%

N,N-diethyl-2-phenylacetamide Structure

2431-96-1

N,N-diethyl-2-p...

Benzeneacetamide,N,N-diethyl-a-phenyl- Structure

3004-58-8

Benzeneacetamid...

N,N-Diethylacetamide Structure

685-91-6

N,N-Diethylacetamide

~%

Benzeneacetamide,N,N-diethyl-a-phenyl- Structure

3004-58-8

Benzeneacetamid...

Bromobenzene Structure

108-86-1

Bromobenzene

~%

Benzeneacetamide,N,N-diethyl-a-phenyl- Structure

3004-58-8

Benzeneacetamid...

Chlorobenzene Structure

108-90-7

Chlorobenzene

~%

Benzeneacetamide,N,N-diethyl-a-phenyl- Structure

3004-58-8

Benzeneacetamid...

Bromobenzene Structure

108-86-1

Bromobenzene

N,N-Dimethylacetamide Structure

127-19-5

N,N-Dimethylace...

~86%

Benzeneacetamide,N,N-dimethyl- Structure

18925-69-4

Benzeneacetamid...

Bromobenzene Structure

108-86-1

Bromobenzene

N,N-DIISOPROPYLFORMAMIDE Structure

759-22-8

N,N-DIISOPROPYL...

~89%

Benzeneacetamide,N,N-bis(1-methylethyl)- Structure

34251-46-2

Benzeneacetamid...


Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved