Correlations of antihypertensive and antisecretory activities with various structural modifications of the antihypertensive agent clonidine [2-(2, 6-dichlorophenylimino) imidazolidine] are described. Eleven chemical classes of compounds containing an “amidine” moiety were prepared in this study. The antihypertensive activity of these compounds was evaluated in metacorticoid hypertensive rats and unanesthetized ...
