4-(3, 4-Dihydroxyphenyl)-1, 2, 3, 4-tetrahydroisoquinoline derivatives. II. Their renal vasodilation activity and structure-activity relationship.

H ANAN, A TANAKA, R TSUZUKI, M YOKOTA…

Index: Anan, Hideki; Tanaka, Akihiro; Tsuzuki, Ryuji; Yokota, Masaki; Yatsu, Takeyuki; Fujikura, Takashi Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 10 p. 1865 - 1870

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Citation Number: 13

Abstract

A series of 4-(3, 4-dihydroxyphenyl)-1, 2, 3, 4-tetrahydroisoquinoline derivatives showed potent DA 1 agonistic activities. We investigated the structure-activity relationship of the racemic compounds of this series. 4-(3, 4-Dihydroxyphenyl)-7-methanesulfonamido-1, 2, 3, 4-tetrahydroisoquinoline (43) was identified as a potent renal vasodilator with activity almost equal to that of YM435 (1).