Tetrahedron Letters

An efficient method for demethylation of aryl methyl ethers

L Zuo, S Yao, W Wang, W Duan

Index: Zuo, Li; Yao, Shanyan; Wang, Wei; Duan, Wenhu Tetrahedron Letters, 2008 , vol. 49, # 25 p. 4054 - 4056

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Citation Number: 37

Abstract

The phenolic hydroxyl group can be found in a large number of natural products and biologically important substances. The protection of the phenol moiety is often mandatory during the synthesis of any phenol-containing product as a result of its high sensitivity toward other reagents. Methylation of phenolic hydroxyl groups is one of the most commonly used means for the protection of the functionality in organic synthesis. 1 The highly stable protected methyl ether form can be ...