Multifunctional antioxidants for the treatment of age-related diseases

…, J Randazzo, P Zhang, PF Kador

Index: Jin, Hongxia; Randazzo, James; Zhang, Peng; Kador, Peter F. Journal of Medicinal Chemistry, 2010 , vol. 53, # 3 p. 1117 - 1127

Full Text: HTML

Citation Number: 30

Abstract

Analogues of N, N-dimethyl-4-(pyrimidin-2-yl) piperazine-1-sulfonamide possessing a free radical scavenger group (FRS), chelating groups (CHL), or both (FRS+ CHL) have been synthesized. Electrospray ionization mass spectrometry studies indicate that select members of this series bind ions in the relative order of Cu1+= Cu2+> Fe2+= Fe3+> Zn2+ with no binding of Ca2+ or Mg2+ observed. In vitro evaluation of these compounds in human lens ...

~74%

~10%

~10%

Pyridine and pyrimidine analogs of acetaminophen as inhibito...

[Nam, Tae-Gyu; Nara, Susheel J.; Zagol-Ikapitte, Irene; Cooper, Thomas; Valgimigli, Luca; Oates, John A.; Porter, Ned A.; Boutaud, Olivier; Pratt, Derek A. Organic and Biomolecular Chemistry, 2009 , vol. 7, # 24 p. 5103 - 5112]

Structure-based design of novel class II c-Met inhibitors: 2...

[Liu, Longbin; Norman, Mark H.; Lee, Matthew; Xi, Ning; Siegmund, Aaron; Boezio, Alessandro A.; Booker, Shon; Choquette, Debbie; D'Angelo, Noel D.; Germain, Julie; Yang, Kevin; Yang, Yajing; Zhang, Yihong; Bellon, Steven F.; Whittington, Douglas A.; Harmange, Jean-Christophe; Dominguez, Celia; Kim, Tae-Seong; Dussault, Isabelle Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 1868 - 1897]