Pyridine and pyrimidine analogs of acetaminophen as inhibitors of lipid peroxidation and cyclooxygenase and lipoxygenase catalysis

T Nam, SJ Nara, I Zagol-Ikapitte, T Cooper…

Index: Nam, Tae-Gyu; Nara, Susheel J.; Zagol-Ikapitte, Irene; Cooper, Thomas; Valgimigli, Luca; Oates, John A.; Porter, Ned A.; Boutaud, Olivier; Pratt, Derek A. Organic and Biomolecular Chemistry, 2009 , vol. 7, # 24 p. 5103 - 5112

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Citation Number: 33

Abstract

Herein we report an investigation of the efficacy of pyridine and pyrimidine analogs of acetaminophen (ApAP) as peroxyl radical-trapping antioxidants and inhibitors of enzyme- catalyzed lipid peroxidation by cyclooxygenases (COX) and lipoxygenases (LOX). In inhibited autoxidations we find that ApAP, the common analgesic and antipyretic agent, is a very good antioxidant with a rate constant for reaction with peroxyl radicals (kinh= 5× 105 ...