Multifunctional antioxidants for the treatment of age-related diseases

…, J Randazzo, P Zhang, PF Kador

文献索引：Jin, Hongxia; Randazzo, James; Zhang, Peng; Kador, Peter F. Journal of Medicinal Chemistry, 2010 , vol. 53, # 3 p. 1117 - 1127

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被引用次数: 30

摘要

Analogues of N, N-dimethyl-4-(pyrimidin-2-yl) piperazine-1-sulfonamide possessing a free radical scavenger group (FRS), chelating groups (CHL), or both (FRS+ CHL) have been synthesized. Electrospray ionization mass spectrometry studies indicate that select members of this series bind ions in the relative order of Cu1+= Cu2+> Fe2+= Fe3+> Zn2+ with no binding of Ca2+ or Mg2+ observed. In vitro evaluation of these compounds in human lens ...