Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities

H Tang, Y Yan, Z Feng, RK de Jesus, L Yang…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 20 p. 6088 - 6092

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Citation Number: 14

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... The structures of the two most potent hits are shown in Figure 2. In this communication, we will outline the medicinal chemistry efforts leading to the discovery of a novel class of MCD inhibitors containing the 1,1,1,3,3,3-hexafluoro ...