e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Synthesis and biological evaluation of 1-(isoxazol-5-ylmethylaminoethyl)-4-phenyl tetrahydropyridine and piperidine derivatives as potent T-type calcium channel …

…, G Nam, SB Kang, AN Pae, N Jeong, G Keum

Index: Lee, Ju-Hyeon; Seo, Seon Hee; Lim, Eun Jeong; Cho, Nam-Chul; Nam, Ghilsoo; Kang, Soon Bang; Pae, Ae Nim; Jeong, Nakcheol; Keum, Gyochang European Journal of Medicinal Chemistry, 2014 , vol. 74, p. 246 - 257

Full Text: HTML

Citation Number: 8

Abstract

Abstract New tetrahydropyridinyl and piperidinyl ethylamine derivatives were designed with hypothetical mapping on pharmacophore model generated from ligand-based virtual screening. The designed compounds were synthesized, and their inhibitory activities on T- type calcium channel were assayed using FDSS and patch-clamp assay. Among them, compounds 7b and 10b showed potent T-type calcium current blocking activity against Ca ...

Tributyltin hydride Structure

Tributyltin hydride

N-(tert-Butoxycarbonyl)-4-piperidone Structure

N-(tert-Butoxyc...

~44%

t-Butoxycarbonyl-4-Tributylstannyl-1,2,3,6-tetrahydropyridine Structure

t-Butoxycarbony...

1-Piperidinecarboxylic acid, 4-phenyl-, 1,1-dimethylethyl ester Structure

1-Piperidinecar...

~99%

4-Phenylpiperidine Structure

4-Phenylpiperidine

4-(4-Chloro-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester Structure

4-(4-Chloro-phe...

~99%

4-(4-Chlorophenyl)1,2,3,6- Structure

4-(4-Chlorophen...

N-(tert-Butoxycarbonyl)-4-piperidone Structure

N-(tert-Butoxyc...

~%

4-(4-Chlorophenyl)1,2,3,6- Structure

4-(4-Chlorophen...

4-phenyl-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester Structure

4-phenyl-3,6-di...

~84%

1-Piperidinecarboxylic acid, 4-phenyl-, 1,1-dimethylethyl ester Structure

1-Piperidinecar...

Bromobenzene Structure

N-(tert-Butoxycarbonyl)-4-piperidone Structure

N-(tert-Butoxyc...

~68%

4-phenyl-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester Structure

4-phenyl-3,6-di...

4-Phenylpiperidine Structure

4-Phenylpiperidine

~%

2-(4-phenylpiperidin-1-yl)ethanamine Structure

2-(4-phenylpipe...

N-(tert-Butoxycarbonyl)-4-piperidone Structure

N-(tert-Butoxyc...

~%

2-(4-phenylpiperidin-1-yl)ethanamine Structure

2-(4-phenylpipe...

1-Piperidinecarboxylic acid, 4-phenyl-, 1,1-dimethylethyl ester Structure

1-Piperidinecar...

~%

2-(4-phenylpiperidin-1-yl)ethanamine Structure

2-(4-phenylpipe...

4-phenyl-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester Structure

4-phenyl-3,6-di...

~%

2-(4-phenylpiperidin-1-yl)ethanamine Structure

2-(4-phenylpipe...

Bromobenzene Structure

~%

2-(4-phenylpiperidin-1-yl)ethanamine Structure

2-(4-phenylpipe...

N/A Structure

~92%

4-(3,4-Dichlorophenyl)piperidine Structure

4-(3,4-Dichloro...

N-(tert-Butoxycarbonyl)-4-piperidone Structure

N-(tert-Butoxyc...

~%

4-(3,4-Dichlorophenyl)piperidine Structure

4-(3,4-Dichloro...

4-Bromo-1,2-dichlorobenzene Structure

4-Bromo-1,2-dic...

~%

4-(3,4-Dichlorophenyl)piperidine Structure

4-(3,4-Dichloro...

1-(tert-Butoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yl trifluoromethanesulfonate Structure

1-(tert-Butoxyc...

~%

4-(3,4-Dichlorophenyl)piperidine Structure

4-(3,4-Dichloro...

1,2,3,6-Tetrahydropyridine-4-boronic acid pinacol ester Structure

1,2,3,6-Tetrahy...

~%

4-(3,4-Dichlorophenyl)piperidine Structure

4-(3,4-Dichloro...

N/A Structure

~%

4-(3,4-Dichlorophenyl)piperidine Structure

4-(3,4-Dichloro...