Tetrahedron Letters

On the scope of radical reactions in aqueous media utilizing quaternary ammonium salts of phosphinic acids as chiral and achiral hydrogen donors

VT Perchyonok, KL Tuck, SJ Langford, MW Hearn

Index: Perchyonok; Tuck, Kellie L.; Langford, Steven J.; Hearn, Milton W. Tetrahedron Letters, 2008 , vol. 49, # 32 p. 4777 - 4779

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Citation Number: 20

Abstract

A broad range of fundamental free radical reactions such as hydrogen atom transfer, radical deoxygenations, and radical cyclizations utilizing quaternary ammonium salts of phosphinic acids as chiral and achiral hydrogen donors at room temperature are investigated. The reactions proceed in good to excellent yields with some degree of enantioselectivity.

~80%

~85%

~47%

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