Exclusive aromatic vs aliphatic C–H bond functionalization by carbene insertion with gold-based catalysts

I Rivilla, BP Gómez-Emeterio, MR Fructos…

Index: Rivilla, Ivan; Gomez-Emeterio, B. Pilar; Fructos, Manuel R.; Diaz-Requejo, M. Mar; Perez, Pedro J. Organometallics, 2011 , vol. 30, # 10 p. 2855 - 2860

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Citation Number: 60

Abstract

The direct functionalization of aromatic C–H bonds by carbene insertion from diazo compounds catalyzed by gold complexes with N-heterocyclic ligands is described. The reaction is completely selective toward the Csp2–H bonds, other Csp3–H bonds remaining unreacted. A study with several NHC ligands in Au (I) and Au (III) complexes has been performed. The potential application of this strategy to give profen derivatives has also ...