Oriental Journal of Chemistry

Synthesis and antimicrobial evaluation of 5-(p-substituted phenyl)-N-(3-(5-nitrofur-2-yl) allylidene)-1, 3, 4-thiadiazol-2-amine derivatives

N Salih, J Salimon, E Yousif

Index: Salih, Nadia; Salimon, Jumat; Yousif, Emad Oriental Journal of Chemistry, 2011 , vol. 27, # 2 p. 373 - 383

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Citation Number: 4

Abstract

ABSTRACT 5-(p-Substituted phenyl)-N-(3-(5-nitrofur-2-yl) allylidene)-1, 3, 4-thiadiazol-2- amines 10-17 were prepared utilizing different p-substituted benzoic acid through two step reactions. Firstly, thiosemicarbzide was reacted with benzoic acid derivatives 1 in the presence of phosphorus oxychloride to give 2-amino-5-substituted-1, 3, 4-thiadiazoles 2-9. These compounds were reacted with 5-nitro-2-furanacrolein to yield the target products. ...