Synthesis and biological activity of selected 2-substituted 6-(. beta.-D-ribofuranosyl) oxazolo [5, 4-d] pyrimidin-7-ones

…, DS Wise, LB Townsend, A Bloch

Index: Patil; Wise; Townsend; Bloch Journal of Medicinal Chemistry, 1974 , vol. 17, # 12 p. 1282 - 1285

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Citation Number: 14

Abstract

Several 2-substituted 6-(~-o-ribofuranosyl) oxazolo [~, 4-d] pyrimidin-7-ones have been prepared by condensation of the appropriate silylated heterocyles with 2, 3, 5-tri-O-acetyl-/3- ~-ribofuranosyl bromide and the subsequent removal of blocking groups from the carbohydrate moiety with methanolic ammonia. The site of ribosylation was established by comparison of the uv spectra of the nucleosides with that of an appropriate model ...