Topically active carbonic anhydrase inhibitors. 4.[(Hydroxyalkyl) sulfonyl] benzene and [(hydroxyalkyl) sulfonyl] thiophenesulfonamides

…, SL Graham, RJ Hudcosky, SR Michelson…

Index: Shepard; Graham; Hudcosky; Michelson; Scholz; Schwam; Smith; Sondey; Strohmaier; Sugrue Journal of Medicinal Chemistry, 1991 , vol. 34, # 10 p. 3098 - 3105

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Citation Number: 22

Abstract

For several decades a tantalizing goal for the treatment of primary open-angle glaucoma has been the development of a topically active carbonic anhydrase inhibitor. Rscent reaulta from several research group indicata that considerable progress has been made toward this objective. In this report, we present the design and synthesis of (hydroxy-alky1) sulfonyl- substituted benzene-and thiophenesulfonamides. These compounds exhibit inhibition of ...