The Alkylation of Coumarin at C-3 of 4-Hydroxycoumarin

I Tabakovic, K Tabakovic, I Gaon

Index: Tabakovic, Ibro; Tabakovic, Katmerka; Gaon, Igor Organic Preparations and Procedures International, 1997 , vol. 29, # 2 p. 223 - 226

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Citation Number: 8

Abstract

Several important natural compounds have an alkyl chain at C-3 on 4-hydroxycoumarin.' Compounds comprising 4-hydroxycoumarin nucleus are reported to have anthelmintic, hypnotic, insecticidal, antifungal activities and anticoagulant effect. 2 In an attempt to synthesize 3-geranylcoumarin, which is one of the natural coumarins,'4-hydroxycoumarin was treated with geranyl bromide in the presence of K2C0,, and the desired product was ...