The Journal of organic chemistry

Reaction of Phosgeniminium Salts with Enolates Derived from Lewis Acid Complexes of 2'-Hydroxypropiophenones and Related β-Diketones

J Morris, GP Luke, DG Wishka

Index: Morris, Joel; Luke, George P.; Wishka, Donn G. Journal of Organic Chemistry, 1996 , vol. 61, # 9 p. 3218 - 3220

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Citation Number: 32

Abstract

The 2-aminochromone ring system has proven to be a rich pharmacophore for use in the design of compounds with a diversity of biological effects that includes unique antiplatelet derivatives, 1 antiproliferative agents, 2 and phosphatidylinositol 3-kinase inhibitors. 3 Our interest in the utilization of this template4, 5 as well as the related 2-aminopyrone system6 as part of our medicinal chemistry efforts led us to explore a variety of new methods for ...

~90%

Model studies for a molecular mechanism of action of oral an...

[Silverman, Richard B. Journal of the American Chemical Society, 1981 , vol. 103, # 13 p. 3910 - 3915]

Synthesis of Coumarins, 4-Hydroxycoumarins, and 4-Hydroxyqui...

[Dittmer, Donald C.; Li, Qun; Avilov, Dimitry V. Journal of Organic Chemistry, 2005 , vol. 70, # 12 p. 4682 - 4686]

The chemistry of coumarin derivatives. Part 3. Synthesis of ...

[Appendino, Giovanni; Cravotto, Giancarlo; Tagliapietra, Silvia; Ferraro, Stefano; Nano, Gian Mario; Palmisano, Giovanni Helvetica Chimica Acta, 1991 , vol. 74, # 7 p. 1451 - 1458]

The Alkylation of Coumarin at C-3 of 4-Hydroxycoumarin

[Tabakovic, Ibro; Tabakovic, Katmerka; Gaon, Igor Organic Preparations and Procedures International, 1997 , vol. 29, # 2 p. 223 - 226]