The Journal of organic chemistry

Reaction of Phosgeniminium Salts with Enolates Derived from Lewis Acid Complexes of 2'-Hydroxypropiophenones and Related β-Diketones

J Morris, GP Luke, DG Wishka

文献索引：Morris, Joel; Luke, George P.; Wishka, Donn G. Journal of Organic Chemistry, 1996 , vol. 61, # 9 p. 3218 - 3220

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被引用次数: 32

摘要

The 2-aminochromone ring system has proven to be a rich pharmacophore for use in the design of compounds with a diversity of biological effects that includes unique antiplatelet derivatives, 1 antiproliferative agents, 2 and phosphatidylinositol 3-kinase inhibitors. 3 Our interest in the utilization of this template4, 5 as well as the related 2-aminopyrone system6 as part of our medicinal chemistry efforts led us to explore a variety of new methods for ...