Dihydroergot Analogs. 1-(3-Indolylmethyl)-piperidinecarboxamides1

AP Swain, SK Naegele

Index: Swain; Naegele Journal of the American Chemical Society, 1957 , vol. 79, p. 5250,5252

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Citation Number: 11

Abstract

Many of these substituted piperidine amides cause a decrease in blood pressure after intravenous injection into dogs anesthetized with a-chloralose. The N, N-diethylamide of 1- (3-indolylmethyl)-isonipecotic acid (Table I) lowers the blood pressure, decreases the heart rate and blocks the pressor rise resulting from bilateral carotid occlusion at dose levels ranging from 2 to 16 mg./kg. The isomers having the diethylamide group in the 2-or 3- ...