Cross coupling of acyl and aminyl radicals: direct synthesis of amides catalyzed by Bu4NI with TBHP as an oxidant

Z Liu, J Zhang, S Chen, E Shi, Y Xu…

Index: Liu, Zhaojun; Zhang, Jie; Chen, Shulin; Shi, Erbo; Xu, Yuan; Wan, Xiaobing Angewandte Chemie - International Edition, 2012 , vol. 51, # 13 p. 3231 - 3235

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Citation Number: 237

Abstract

Amides are prevalent structural motifs that are found in biologically relevant molecules, such as proteins, as well as natural products, marketed drugs, and synthetic intermediates.[1] As a result, the synthesis of amides has attracted considerable interest and a number of methods have been devised. Conventionally, amides are synthesized by coupling a carboxylic acid or a carboxylic acid derivative with an amine.[1a, b, 2, 3] In addition, the ...