A Fmoc/Boc pseudoisocytosine monomer for peptide nucleic acid synthesis

F Wojciechowski, RHE Hudson

Index: Wojciechowski, Filip; Hudson, Robert H. E. Canadian Journal of Chemistry, 2008 , vol. 86, # 11 p. 1026 - 1029

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Citation Number: 4

Abstract

The synthesis of N-[2-(fluorenylmethoxycarbonyl) aminoethyl]-N-[(2-N-(tert-butoxycarbonyl) isocytosin-5-yl) acetyl] glycine peptide nucleic acid monomer is described. The N-tert- butoxycarbonyl protected monomer is compatible with commercially available monomers designed for the Fmoc-oligomerization strategy and is deprotected under mild acidolysis conditions. Key words: PNA, polyamide, pseudoisocytosine, J-base, triplex.