Novel N-(4-piperidinyl) benzamide antimalarials with mammalian protein farnesyltransferase inhibitory activity

A Ryckebusch, P Gilleron, R Millet, R Houssin…

Index: Chemical and Pharmaceutical Bulletin, , vol. 53, # 10 p. 1324 - 1326

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Citation Number: 13

Abstract

... imidazoleacetic esters: tritylation of N1-imidazole (4), protection of primary alcohol as ester (5), benzylation of N3 and detritylation of N1 (6a— c). The aldehyde function was finally created by chemical ox- idation ... 2005 Pharmaceutical Society of ... 53(10) 1324—1326 (2005) Vol. ...

Practical multigram synthesis for 4 (5)-vinylimidazole

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Synthesis of L??histidine specifically labelled with stable ...

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Structure-based design of imidazole-containing peptidomimeti...

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