Preparation of 7-halo-indoles by thallation of N-formylindoline and their attempted use for synthesis of the right-hand segment of chloropeptin

Y Yamada, S Arima, C Okada, A Akiba, T Kai…

Index: Yamada, Yaeko; Arima, Shiho; Okada, Chiharu; Akiba, Ai; Kai, Toshitsugu; Harigaya, Yoshihiro Chemical and Pharmaceutical Bulletin, 2006 , vol. 54, # 6 p. 788 - 794

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Citation Number: 14

Abstract

7-Substituted (Cl, Br, I) indoles were synthesized by using thallation of N-formylindoline as a key reaction. Two precursor tripeptides for the right-hand segment of chloropeptin were synthesized by using (R)-7′-iodo and 7′-bromotryptophans derived from each 7- substituted indole (I, Br) obtained by the above procedure.