Tetrahedron letters

The first microwave-assisted regiospecific synthesis of 6-substituted pterins

S Goswami, AK Adak

Index: Goswami, Shyamaprosad; Adak, Avijit Kumar Tetrahedron Letters, 2002 , vol. 43, # 46 p. 8371 - 8373

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Citation Number: 58

Abstract

The pyrazine ring was developed in a pyrimidine and in a benzene by Isay type condensations under microwave irradiation to afford pterin and quinoxaline systems. Interestingly, the desired isomerically free 6-substituted pterins including pterin sugar derivatives were synthesised in moderate to good yields whereas mixtures of both 6-and 7- isomers (major) are generally obtained using conventional Isay type condensations.