Bis-Ammonium Salts. Unsymmetric Derivatives of Substituted Pyridine Bases that Are Potent and Selective Hypotensive Agents1

AP Gray, WL Archer, EE Spinner…

Index: Gray et al. Journal of the American Chemical Society, 1957 , vol. 79, p. 3805,3807

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Citation Number: 13

Abstract

Reports from these laboratories have described several series of unsymmetric bis- quaternary salts in which hypotensive and peripheral autonomic blocking activity could be independently varied. 2 A central component of action was impli~ ated.~.~ In our earlier reports, requirements for biological activity had been quite sharply delineated with respect to size of the small cationic head, distance between charged nitrogens, charge distribution ...