Bis-Ammonium Salts. Unsymmetric Derivatives of Substituted Pyridine Bases that Are Potent and Selective Hypotensive Agents1

AP Gray, WL Archer, EE Spinner…

文献索引：Gray et al. Journal of the American Chemical Society, 1957 , vol. 79, p. 3805,3807

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被引用次数: 13

摘要

Reports from these laboratories have described several series of unsymmetric bis- quaternary salts in which hypotensive and peripheral autonomic blocking activity could be independently varied. 2 A central component of action was impli~ ated.~.~ In our earlier reports, requirements for biological activity had been quite sharply delineated with respect to size of the small cationic head, distance between charged nitrogens, charge distribution ...