Palladium-catalyzed intermolecular α-arylation of zinc amide enolates under mild conditions

T Hama, DA Culkin, JF Hartwig

Index: Hama, Takuo; Liu, Xiaoxiang; Culkin, Darcy A.; Hartwig, John F. Journal of the American Chemical Society, 2003 , vol. 125, # 37 p. 11176 - 11177

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Citation Number: 134

Abstract

The intermolecular α-arylation and vinylation of amides by palladium-catalyzed coupling of aryl bromides and vinyl bromides with zinc enolates of amides is reported. Reactions of three different types of zinc enolates have been developed. The reactions of aryl halides occur in high yields with isolated Reformatsky reagents generated from α-bromo amides, with Reformatsky reagents generated in situ from α-bromo amides, and with zinc enolates ...