Pyrrolo [3, 2-d] pyrimidines. IV. Synthesis and antibacterial and antitumor activity of 2, 4, 7-substituted pyrrolo [3, 2-d] pyrimidines

…, NE Britikova, KY Novitskii, LI Shcherbakova…

Index: Sizova, O. S.; Britikova, N. E.; Novitskii, K. Yu.; Shcherbakova, L. I.; Pershin, G. N.; et al. Pharmaceutical Chemistry Journal, 1982 , vol. 16, # 11 p. 834 - 838 Khimiko-Farmatsevticheskii Zhurnal, 1982 , vol. 16, # 11 p. 1338 - 1343

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Abstract

We have synthesized 2-phenyl-4-chloro-7-cyanopyrrolo [3, 2-d] pyrimidine (III) from: the aldehyde (I)(2), by conversion of the oxime (II) followed by dehydration of the latter with phosphoryl chloride. The oxime (II) could not be isolated in an analytically pure state, but its structure was proved unambiguously by IR spectroscopy as well as by the preparation of its nitrile (III).