Triazole ligands reveal distinct molecular features that induce histamine H4 receptor affinity and subtly govern H4/H3 subtype selectivity

M Wijtmans, C de Graaf, G de Kloe…

Index: Journal of Medicinal Chemistry, , vol. 54, # 6 p. 1693 - 1703

Full Text: HTML

Citation Number: 31

Abstract

... Journal of Medicinal ... The imidazole ring posed some problems in the click chemistry putatively due to Cu(II) coordination, but Boc protection of the ... possible roles in pain modulation and (breast) cancer have been revealed.(13, 14) The high interest of medicinal chemists for H 4 ...