Triazole ligands reveal distinct molecular features that induce histamine H4 receptor affinity and subtly govern H4/H3 subtype selectivity

M Wijtmans, C de Graaf, G de Kloe…

文献索引：Journal of Medicinal Chemistry, , vol. 54, # 6 p. 1693 - 1703

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被引用次数: 31

摘要

... Journal of Medicinal ... The imidazole ring posed some problems in the click chemistry putatively due to Cu(II) coordination, but Boc protection of the ... possible roles in pain modulation and (breast) cancer have been revealed.(13, 14) The high interest of medicinal chemists for H 4 ...