Total synthesis of pseudomonic acid C

GE Keck, DF Kachensky, EJ Enholm

Index: Keck, Gary E.; Kachensky, David F.; Enholm, Eric J. Journal of Organic Chemistry, 1984 , vol. 49, # 8 p. 1462 - 1464

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Citation Number: 18

Abstract

IC A key element of the synthetic strategy detailed below is recognition of the structure of (+)-pseudomonic acid C as that of a highly modified L-lyxose, a commercially available sugar. Thus the synthetic planning may be re- duced to the synthesis of the requisite "upper" and "lower" appendages for incorporation at C1 and C4, respectively, coupled with appropriate means for their stereocontrolled introduction. In this context, it should be noted that the C5 ...