Evaluation of a Series of Naphthamides as Potent, Orally Active Vascular Endothelial Growth Factor Receptor-2 Tyrosine Kinase Inhibitors¶

MM Weiss, JC Harmange, AJ Polverino…

Index: Nomoto; Obase; Takai; Hirata; Teranishi; Nakamu ra; Kubo Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 6 p. 1591 - 1595

Full Text: HTML

Citation Number: 39

Abstract

... 51 (6), pp 1668–1680. DOI: 10.1021/jm701098w. Publication Date (Web): March 7, 2008. Copyright © 2008 American Chemical Society. ¶ ... Department of Medicinal Chemistry. ... the growth and metastasis of solid tumors.(1, 2) Tumors smaller than 2 mm 3 in volume acquire nutrients ...

~76%

Potent 1, 3, 4-trisubstituted pyrrolidine CCR5 receptor anta...

[Kim, Dooseop; Wang, Liping; Hale, Jeffrey J.; Lynch, Christopher L.; Budhu, Richard J.; MacCoss, Malcolm; Mills, Sander G.; Malkowitz, Lorraine; Gould, Sandra L.; Demartino, Julie A.; Springer, Martin S.; Hazuda, Daria; Miller, Michael; Kessler, Joseph; Hrin, Renee C.; Carver, Gwen; Carella, Anthony; Henry, Karen; Lineberger, Janet; Schleif, William A.; Emini, Emilio A. Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 8 p. 2129 - 2134]