Potent 1, 3, 4-trisubstituted pyrrolidine CCR5 receptor antagonists: effects of fused heterocycles on antiviral activity and pharmacokinetic properties

…, RJ Budhu, M MacCoss, SG Mills, L Malkowitz…

Index: Kim, Dooseop; Wang, Liping; Hale, Jeffrey J.; Lynch, Christopher L.; Budhu, Richard J.; MacCoss, Malcolm; Mills, Sander G.; Malkowitz, Lorraine; Gould, Sandra L.; Demartino, Julie A.; Springer, Martin S.; Hazuda, Daria; Miller, Michael; Kessler, Joseph; Hrin, Renee C.; Carver, Gwen; Carella, Anthony; Henry, Karen; Lineberger, Janet; Schleif, William A.; Emini, Emilio A. Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 8 p. 2129 - 2134

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Citation Number: 97

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A series of 1,3,4-trisubstituted pyrrolidine CCR5 receptor antagonists containing a variety of fused heterocycles at the 4-position of the piperidine side chain has been discovered, which are orally bioavailable with potent anti-HIV activity. ... 1,3,4-Trisubstituted pyrrolidine CCR5 antagonists. 1,3,4- ...