Abstract The layered double hydroxides-supported diisopropylamide (LDH-DA) catalyst is found to be an efficient and selective solid base for aldol, Knoevenagel, Henry, Michael, transesterification and epoxidation reactions under liquid phase conditions. LDH-DA is synthesized by the interaction of lithium diisopropylamide with LDH-NO 3 (as-synthesized) and calcined LDH-NO 3. The LDH-DA (Mg/Al, 3/1) and their precursors are well ...