Unsymmetrically disubstituted urea derivatives: A potent class of antiglycating agents

…, M Ali, M Gohar, J Zahid, A Khan, S Perveen…

Index: Khan, Khalid M.; Saeed, Sumayya; Ali, Muhammad; Gohar, Madiha; Zahid, Javariya; Khan, Ambreen; Perveen, Shahnaz; Choudhary, M. Iqbal Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 6 p. 2447 - 2451

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Citation Number: 52

Abstract

A series of unsymmetrically disubstituted urea derivatives 1–28 has been synthesized and screened for their antiglycation activity in vitro. Compounds 26 (IC50= 4.26±0.25 μM), 1 (IC50= 5.8±0.08 μM), 22 (IC50= 4.26±0.25 μM), 6 (IC50= 6.4±0.02 μM), 5 (IC50= 6.6±0.26 μM), 2 (IC50= 7.02±0.31 μM), 3 (IC50= 7.14±0.84 μM), 27 (IC50= 7.27±0.36 μM), 4 (IC50= 8.16±1.04 μM), 21 (IC50= 8.4±0.15 μM), 23 (IC50= 9.0±0.35 μM) and 13 (IC50= 15.22±6.7 ...