Die Pharmazie

[Biotransformation of denaverin (Spasmalgan) in the rat]

B Göber, H Lisowski, D Friese, P Franke

Index: Goeber, B.; Lisowski, Hannelore; Friese, Dagmar; Franke, P. Pharmazie, 1988 , vol. 43, # 7 p. 493 - 495

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Citation Number: 5

Abstract

After oral application of denaverine hydrochloride to rats (200-250 mg/kg) 12 metabolites have been detectecd in urine. Besides the unchanged drug, 8 metabolites were identified by MS as 2, 2-diphenyl-(2-dimethylaminoethyl) acetate (3), diphenylacetic (5) and benzilic acid (6); methyl-and ethyl [2-(2-ethylbutoxy)-2, 2-diphenyl] acetate (7, 11), methylbenzilate (10), N- demethyl-1 (12) and 3, 3-diphenyl-morpholin-2-one (13). 6 and the metabonate 13 ...