Development of N-substituted hydroxylamines as efficient nitroxyl (HNO) donors

…, MA Siegler, CD Moore, JP Toscano

Index: Guthrie, Daryl A.; Kim, Nam Y.; Siegler, Maxime A.; Moore, Cathy D.; Toscano, John P. Journal of the American Chemical Society, 2012 , vol. 134, # 4 p. 1962 - 1965

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Citation Number: 24

Abstract

Due to its inherent reactivity, nitroxyl (HNO), must be generated in situ through the use of donor compounds, but very few physiologically useful HNO donors exist. Novel N- substituted hydroxylamines with carbon-based leaving groups have been synthesized, and their structures confirmed by X-ray crystallography. These compounds generate HNO under nonenzymatic, physiological conditions, with the rate and amount of HNO released being ...