Meridianin G and its analogs as antimalarial agents

…, BL Tekwani, MR Jacob, IA Khan, RA Vishwakarma

Index: Bharate, Sandip B.; Yadav, Rammohan R.; Khan, Shabana I.; Tekwani, Babu L.; Jacob, Melissa R.; Khan, Ikhlas A.; Vishwakarma, Ram A. MedChemComm, 2013 , vol. 4, # 6 p. 1042 - 1048

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Citation Number: 12

Abstract

Meridianin C and G showed antimalarial activity against both chloroquine-resistant (D6) as well as sensitive (W2) clones of Plasmodium falciparum with IC 50 values in the range of 4.4 to 14.4 μM. Meridianin G showed better activity against the W2 clone, showing a higher selectivity index> 24.1. Among the analogs, N 1-morpholinoyl