Chinese Chemical Letters

Sodium fluoride as an efficient catalyst for the synthesis of 2, 4-disubstituted-1, 3-thiazoles and selenazoles at ambient temperature

J Banothu, K Vaarla, R Bavantula, PA Crooks

Index: Banothu, Janardhan; Vaarla, Krishnaiah; Bavantula, Rajitha; Crooks, Peter A. Chinese Chemical Letters, 2014 , vol. 25, # 1 p. 172 - 175

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Citation Number: 15

Abstract

Abstract Sodium fluoride was found to be a simple, mild and efficient catalyst for the synthesis of 2, 4-disubstituted 1, 3-thiazoles and selenazoles utilizing phenacyl bromides/3- (2-bromoacetyl)-2H-chromen-2-one and thiourea/phenylthiourea/selenourea in aqueous methanol at ambient temperature. Analytically pure products are formed within 1–3 min in excellent yields.