Tetrahedron Letters

o-Quinone methide based approach to isoflavans: application to the total syntheses of equol, 3′-hydroxyequol and vestitol

…, AM Sathiyanarayanan, P Jonnalagadda

Index: Gharpure, Santosh J.; Sathiyanarayanan; Jonnalagadda, Prasad Tetrahedron Letters, 2008 , vol. 49, # 18 p. 2974 - 2978

Full Text: HTML

Citation Number: 32

Abstract

A concise strategy is developed for the synthesis of isoflavans employing a Diels–Alder reaction between o-quinone methides and aryl-substituted enol ethers followed by reductive cleavage of the acetal group. The method is extended towards the total syntheses of equol, 3′-hydroxyequol and vestitol.